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Miriplatin hydrate

CAS No. 250159-48-9

Miriplatin hydrate( —— )

Catalog No. M33717 CAS No. 250159-48-9

Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Miriplatin hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).
  • Description
    Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.
  • In Vitro
    Miriplatin suspended in lipiodol (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis.
  • In Vivo
    Miriplatin (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DNA Alkylation
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    250159-48-9
  • Formula Weight
    782.01
  • Molecular Formula
    C34H70N2O5Pt
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O.N[C@H]1[C@H](N)CCCC1.O.[Pt+2]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8.?
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